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Table 2 Significant changes in protein expression levels as judged with G-test under p< 0.05 for an LCNEC vs. SCLC pair.

From: Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study

No Entry name Accession number Proteins G P Rsc Spectral counts
        LCNEC SCLC
1 AK1C3 P42330 Aldo-keto reductase family 1 member C3 39.1 3.93E-10 4.91 25 0
2 AK1C1 Q04828 Aldo-keto reductase family 1 member C1 37.4 9.56E-10 4.86 24 0
3 FABP7 O15540 Fatty acid-binding protein, brain 21.9 2.89E-06 4.22 15 0
4 ENOB P13929 Beta-enolase 22.2 2.50E-06 3.61 18 1
5 AL1A1 P00352 Retinal dehydrogenase 1 11.8 6.07E-04 3.55 9 0
6 4F2 P08195 4F2 cell-surface antigen heavy chain 11.8 6.07E-04 3.55 9 0
7 1C12 P30508 HLA class I histocompatibility antigen, Cw-12 alpha chain precursor 11.8 6.07E-04 3.55 9 0
8 TBA4A P68366 Tubulin alpha-4A chain 11.8 6.07E-04 3.55 9 0
9 LG3BP Q08380 Galectin-3-binding protein precursor 20.6 5.77E-06 3.54 17 1
10 1C03 P04222 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor 10.1 1.48E-03 3.40 8 0
11 TKT P29401 Transketolase 8.46 3.62E-03 3.24 7 0
12 VTNC P04004 Vitronectin precursor 6.85 8.87E-03 3.05 6 0
13 G6PD P11413 Glucose-6-phosphate 1-dehydrogenase 6.85 8.87E-03 3.05 6 0
14 PRDX4 Q13162 Peroxiredoxin-4 6.85 8.87E-03 3.05 6 0
15 VDAC1 P21796 Voltage-dependent anion-selective channel protein 1 6.85 8.87E-03 3.05 6 0
16 1B15 P30464 HLA class I histocompatibility antigen, B-15 alpha chain precursor 6.85 8.87E-03 3.05 6 0
17 VILI P09327 Villin-1 6.85 8.87E-03 3.05 6 0
18 DESP P15924 Desmoplakin 11.19 8.24E-04 2.96 11 1
19 AHSA1 O95433 Activator of 90 kDa heat shock protein ATPase homolog 1 5.27 2.18E-02 2.84 5 0
20 COPB P53618 Coatomer subunit beta 5.27 2.18E-02 2.84 5 0
21 TMEDA P49755 Transmembrane emp24 domain-containing protein 10 precursor 5.27 2.18E-02 2.84 5 0
22 CD44 P16070 CD44 antigen precursor 5.27 2.18E-02 2.84 5 0
23 COPA P53621 Coatomer subunit alpha 5.27 2.18E-02 2.84 5 0
24 TBB4Q Q99867 Putative tubulin beta-4q chain 5.27 2.18E-02 2.84 5 0
25 THIL P24752 Acetyl-CoA acetyltransferase, mitochondrial precursor 5.27 2.18E-02 2.84 5 0
26 EFTU P49411 Elongation factor Tu, mitochondrial precursor 14.88 1.14E-04 2.47 19 4
27 IDHP P48735 Isocitrate dehydrogenase [NADP], mitochondrial precursor 13.55 2.32E-04 2.39 18 4
28 LRC47 Q8N1G4 Leucine-rich repeat-containing protein 47 5.41 2.01E-02 2.39 7 1
29 CO6A1 P12109 Collagen alpha-1(VI) chain precursor 4.08 4.34E-02 2.20 6 1
30 PSA P55786 Puromycin-sensitive aminopeptidase 4.08 4.34E-02 2.20 6 1
31 IMB1 Q14974 Importin subunit beta-1 5.95 1.47E-02 2.17 9 2
32 PSA2 P25787 Proteasome subunit alpha type-2 4.72 2.99E-02 2.02 8 2
33 FAS P49327 Fatty acid synthase 9.93 1.63E-03 1.93 18 6
34 A1AT P01009 Alpha-1-antitrypsin precursor 4.05 4.41E-02 1.62 10 4
35 ROA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 6.43 1.12E-02 1.58 16 7
36 FINC P02751 Fibronectin precursor 8.01 4.64E-03 1.57 20 9
37 TRAP1 Q12931 Heat shock protein 75 kDa, mitochondrial precursor 6.26 1.24E-02 1.50 17 8
38 MYH14 Q7Z406 Myosin-14 6.26 1.24E-02 1.50 17 8
39 ANXA2 P07355 Annexin A2 5.46 1.94E-02 1.49 15 7
40 PHB2 Q99623 Prohibitin-2 4.67 3.07E-02 1.49 13 6
41 GSTP1 P09211 Glutathione S-transferase P 10.63 1.12E-03 1.38 32 17
42 PDIA1 P07237 Protein disulfide-isomerase precursor 8.96 2.76E-03 1.33 29 16
43 1433G P61981 14-3-3 protein gamma 8.11 4.40E-03 1.28 28 16
44 ACTN4 O43707 Alpha-actinin-4 8.82 2.98E-03 1.26 31 18
45 PCBP2 Q15366 Poly(rC)-binding protein 2 5.03 2.49E-02 1.16 21 13
46 TPIS P60174 Triosephosphate isomerase 6.45 1.11E-02 1.12 28 18
47 TRFE P02787 Serotransferrin precursor 7.17 7.41E-03 1.12 31 20
48 ARF1 P84077 ADP-ribosylation factor 1 5.00 2.53E-02 1.09 23 15
49 PCBP1 Q15365 Poly(rC)-binding protein 1 4.31 3.79E-02 1.01 23 16
50 CO6A3 P12111 Collagen alpha-3(VI) chain precursor 5.16 2.31E-02 0.91 32 24
51 EF1A1 P68104 Elongation factor 1-alpha 1 4.72 2.98E-02 0.83 35 28
52 PDIA6 Q15084 Protein disulfide-isomerase A6 precursor 4.01 4.52E-02 0.81 31 25
53 G3P P04406 Glyceraldehyde-3-phosphate dehydrogenase 14.21 1.64E-04 0.77 113 95
54 ENPL P14625 Endoplasmin precursor 5.76 1.64E-02 0.66 62 56
55 TBB2A Q13885 Tubulin beta-2A chain 5.80 1.61E-02 0.63 69 64
56 VIME P08670 Vimentin 5.92 1.49E-02 0.60 77 73
57 HBB P68871 Hemoglobin subunit beta 4.88 2.72E-02 -0.53 53 110
58 TBB5 P07437 Tubulin beta chain 10.89 9.64E-04 -0.63 81 179
59 TBA1A Q71U36 Tubulin alpha-1A chain 14.38 1.49E-04 -0.67 93 211
60 TBB2B Q9BVA1 Tubulin beta-2B chain 5.93 1.49E-02 -0.69 35 82
61 H2B1B P33778 Histone H2B type 1-B 6.45 1.11E-02 -0.83 25 65
62 LMNB1 P20700 Lamin-B1 7.27 7.03E-03 -0.87 25 67
63 HBA P69905 Hemoglobin subunit alpha 5.77 1.63E-02 -0.92 17 48
64 CALM P62158 Calmodulin 3.90 4.82E-02 -1.00 9 28
65 HNRH1 P31943 Heterogeneous nuclear ribonucleoprotein H 4.36 3.67E-02 -1.01 10 31
66 NUMA1 Q14980 Nuclear mitotic apparatus protein 1 4.83 2.80E-02 -1.01 11 34
67 LAP2A P42166 Lamina-associated polypeptide 2 isoform alpha 5.31 2.13E-02 -1.05 11 35
68 H31T Q16695 Histone H3.1t 6.23 1.26E-02 -1.06 13 41
69 GDIA P31150 Rab GDP dissociation inhibitor alpha 7.65 5.67E-03 -1.09 15 48
70 TBA1C Q9BQE3 Tubulin alpha-1C chain 14.23 1.62E-04 -1.12 27 86
71 TBA1B P68363 Tubulin alpha-1B chain 35.27 2.88E-09 -1.16 63 202
72 K1C19 P08727 Keratin, type I cytoskeletal 19 10.64 1.11E-03 -1.19 17 58
73 HSP76 P17066 Heat shock 70 kDa protein 6 6.46 1.10E-02 -1.23 9 33
74 H12 P16403 Histone H1.2 7.59 5.87E-03 -1.31 9 35
75 TBB4 P04350 Tubulin beta-4 chain 12.66 3.73E-04 -1.50 11 48
76 MOES P26038 Moesin 4.51 3.36E-02 -1.51 3 16
77 KU70 P12956 ATP-dependent DNA helicase 2 subunit 1 22.32 2.31E-06 -1.64 16 75
78 DYHC1 Q14204 Cytoplasmic dynein 1 heavy chain 1 8.54 3.48E-03 -1.67 5 27
79 RBBP4 Q09028 Histone-binding protein RBBP4 6.58 1.03E-02 -1.74 3 19
80 PGS1 P21810 Biglycan precursor 3.99 4.59E-02 -1.81 1 10
81 ROA1L Q32P51 Heterogeneous nuclear ribonucleoprotein A1-like protein 7.30 6.89E-03 -1.81 3 20
82 HNRPF P52597 Heterogeneous nuclear ribonucleoprotein F 4.77 2.90E-02 -1.93 1 11
83 RUXG P62308 Small nuclear ribonucleoprotein G 6.40 1.14E-02 -2.15 1 13
84 1433S P31947 14-3-3 protein sigma 4.19 4.08E-02 -2.21 0 7
85 PEG10 Q86TG7 Retrotransposon-derived protein PEG10 4.19 4.08E-02 -2.21 0 7
86 CAYP1 Q13938 Calcyphosin 4.19 4.08E-02 -2.21 0 7
87 GBB1 P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 4.19 4.08E-02 -2.21 0 7
88 NCA11 P13591 Neural cell adhesion molecule 1, 140 kDa isoform precursor 4.19 4.08E-02 -2.21 0 7
89 FSCN1 Q16658 Fascin 5.11 2.38E-02 -2.37 0 8
90 ROA0 Q13151 Heterogeneous nuclear ribonucleoprotein A0 8.98 2.74E-03 -2.43 1 16
91 MDHC P40925 Malate dehydrogenase, cytoplasmic 7.00 8.13E-03 -2.66 0 10
92 H2A1D P20671 Histone H2A type 1-D 8.94 2.79E-03 -2.89 0 12
93 SEGN O76038 Secretagogin 15.915 6.63E-05 -3.51 0 19
94 MAP1B P46821 Microtubule-associated protein 1B 16.926 3.89E-05 -3.58 0 20
95 BASP P80723 Brain acid soluble protein 1 24.067 9.30E-07 -3.99 0 27
  1. Proteins are listed in descending order of R sc values, pooled spectral counts are listed, and "_HUMAN" are removed from UniProtKG entry names.
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Journal of Clinical Bioinformatics

ISSN: 2043-9113