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Table 6 Disease ontology terms associated with proteins involved in 3D domain swapping.

From: Functional repertoire, molecular pathways and diseases associated with 3D domain swapping in the human proteome

DO Term Genes P-value
Asthma IL10, TJP1, BCL2L1, IL5 0.001
Amyotrophic lateral sclerosis MET, DCTN1, CST3 0.001
Bronchial hyperreactivity IL10, IL5 0.001
Pulmonary alveolar proteinosis IL10, CST3 0.001
Dental plaque IL10, TJP1, BCL2L1 0.002
Prostate cancer IL10, NCOA2, GLO1, SERPINC1, CST3 0.002
Fatty liver MET, IL10 0.003
Atherosclerosis NOD1, IL10, EPHX2, CST3 0.003
Rabies RNASE1, BCL2L1, SERPINC1 0.004
Parkinson disease IL10, EPHX2, BCL2L1 0.004
Thyroid cancer IL10, TJP1 0.023
Neoplasm metastasis IL10, RNASE1, CST3 0.024
Hypertension IL10, EPHX2, CST3 0.028
Breast cancer IL10, NCOA2, CSTA, CST3 0.05
Lung cancer IL10, CSTA, CSTB 0.057
Adenovirus infection PTK2, BCL2L1 0.072
Abortion NOD1, IL10 0.085
Autistic disorder MET, GLO1 0.096
Kidney disease PTK2, SERPINC1 0.101
Kidney failure IL10, CST3 0.128
Enteritis NOD1, IL10 0.142
Autoimmune disease IL10, BCL2L1 0.148
Systemic scleroderma MET, IL10 0.173
Ulcerative colitis NOD1, IL5 0.18
Multiple sclerosis GLO1, BCL2L1 0.184
Infection NOD1, IL10 0.266
Dermatitis CSTA, IL5 0.294
Cancer MET, PTK2, EPHX2, BCL2L1 0.329
Lupus erythematosus IL10, PTK2 0.378
Melanoma IL10, TJP1 0.41
Alzheimer's disease IL10, CST3 0.713
Embryoma IL10, CST3 0.99
Rheumatoid arthritis BCL2L1, CST3 0.99
Colon cancer NOD1, TJP1 0.99
Leukemia IL10, NCOA2 0.99
Diabetes mellitus TJP1, CST3 0.99
  1. Statistically significant associations are highlighted in bold